Author

E. A. Golemis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Deneka· 2 shared A. Klochkova· 2 shared D. Restifo· 2 shared E. Cukierman· 2 shared E. Nicolas· 2 shared I. Astsaturov· 2 shared I. Bychkov· 2 shared J. Franco-Barraza· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

A. Deneka

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Trogocytosis of cancer-associated fibroblasts promotes pancreatic cancer growth and immune suppression via phospholipid scramblase anoctamin 6 (ANO6).

C. Ogier, A. M. Charles Solomon, Z. Lu, L. Recoules, A. Klochkova, L. Gabitova-Cornell, B. Bayarmagnai, D. Restifo, A. Surumbayeva, D. B. Vendramini-Costa, A. Deneka, R. Francescone, A. C. Lilly, A. Sipman, J. C. Gardiner, , I. Astsaturov

This study identifies ANO6-mediated trogocytosis as a mechanism by which CAFs transfer lipids to PDAC cells, promoting tumor growth and immune suppression.

bioRxiv · Sep 15, 2023 · PreprintCancer Biology

Musashi-2 (MSI2) regulation of DNA damage response in lung cancer

I. Bychkov, A. Deneka, I. Topchu, R. P. Pangeni, C. Lengner, J. Karanicolas, E. A. Golemis, P. Makhov, Y. Boumber

This study shows MSI2 promotes lung tumorigenesis by enhancing ATM expression and DNA damage response, suggesting MSI2 as a potential therapeutic target in lung cancer.

bioRxiv · Jun 13, 2023 · PreprintCancer Biology

Rationally designed inhibitors of the Musashi protein-RNA interaction by hotspot mimicry

N. Bai, Y. Adeshina, I. Bychkov, Y. Xia, R. Gowthaman, S. A. Miller, A. K. Gupta, D. K. Johnson, L. Lan, E. A. Golemis, P. B. Makhov, L. Xu, M. M. Pillai, Y. Boumber, J. Karanicolas

This paper designs inhibitors for Musashi proteins MSI1 and MSI2 by mimicking hotspot pharmacophores from protein-RNA complexes, showing specificity and activity in multiple assays.

bioRxiv · Jan 9, 2023 · PreprintBiochemistry

Cholesterol deprivation induces TGFβ signaling to promote basal differentiation in pancreatic cancer

L. G. Cornell, S. Peri, D. Restifo, A. Klochkova, T. R. Hartman, A. M. O'Reilly, R. Francescone, J. Franco-Barraza, N. Shah, E. Nicolas, E. A. Handorf, K. Q. Cai, A. Mazitova, I. Sloma, R. Chiaverelli, , I. Astsaturov

The paper shows that cholesterol deprivation activates TGFβ signaling, promoting basal differentiation in pancreatic cancer by stabilizing the TGFβ receptor.

bioRxiv · May 11, 2019 · PreprintCancer Biology