Leishmania amazonensis infection induces PD-L1 expression on dendritic cells in an mTor-dependent manner and impairs Th1 responses in vitro and in vivo
H. L. de Matos Guedes, A. M. da Fonseca-Martins, Y. Liang, E. D. Carlsen, C. A. Henard, I. V. Pinchuk, L. Soong
This study shows that Leishmania amazonensis infection increases PD-L1 on dendritic cells via mTOR, leading to impaired Th1 responses and promoting lesion resolution.
bioRxiv · Feb 15, 2022 · PreprintImmunology