L. Soong

Lack of the IFN-γ signal leads to lethal Orientia tsutsugamushi infection in mice with skin eschar lesions

This study shows that lack of IFN-γ signaling leads to lethal Orientia tsutsugamushi infection in mice with skin eschar lesions, highlighting its critical role in immune defense.

Differential cellular immune responses against Orientia tsutsugamushi Karp and Gilliam strains following acute infection in mice

This study compares immune responses in mice infected with two Orientia tsutsugamushi strains, showing differential cellular activation and cytokine profiles linked to disease severity.

Alterations in Germinal Center Formation and B Cell Activation during Severe Orientia tsutsugamushi Infection in Mice

This study investigates B cell and germinal center (GC) responses in mice infected with Orientia tsutsugamushi, finding disrupted GC formation and reduced B cell activation at later stages of infection.

Host transcriptomic profiling of CD-1 outbred mice with severe clinical outcomes following infection with Orientia tsutsugamushi

This study uses CD-1 mice to model severe scrub typhus caused by Orientia tsutsugamushi, finding they exhibit high susceptibility and a Th1/CD8-skewed immune profile associated with disease severity.

Leishmania amazonensis infection induces PD-L1 expression on dendritic cells in an mTor-dependent manner and impairs Th1 responses in vitro and in vivo

This study shows that Leishmania amazonensis infection increases PD-L1 on dendritic cells via mTOR, leading to impaired Th1 responses and promoting lesion resolution.

Combinatorial mRNA vaccination enhances protection against SARS-CoV-2 delta variant

This study shows that combining mRNA vaccines targeting the SARS-CoV-2 spike and nucleoprotein proteins enhances protection against the delta variant in animal models.

EPAC regulates von Willebrand factor secretion from endothelial cells in a PI3K/eNOS-dependent manner during inflammation

This study shows EPAC1 regulates vWF secretion from endothelial cells during inflammation via the PI3K/eNOS pathway, with implications for thrombosis control.

Annexin A2 depletion exacerbates the intracerebral microhemorrhage induced by acute rickettsia and Ebola virus infections

This study shows that ANXA2 depletion increases CMHs in rickettsia and Ebola virus infections by disrupting BBB tight junctions.

Polarized Lung Inflammation and Tie2/Angiopoietin-Mediated Endothelial Dysfunction during Severe Orientia tsutsugamushi Infection

This study investigates lung inflammation and endothelial dysfunction in severe Orientia tsutsugamushi infection, identifying biomarkers of vascular disruption and M1-skewed inflammation.

Protection induced by anti-PD-1 and anti-PD-L1 treatment in Leishmania amazonensis-infected BALB/c mice

This study investigates the therapeutic effects of anti-PD-1 and anti-PD-L1 antibodies in Leishmania amazonensis-infected mice, showing increased IFN-γ production and reduced parasite load.