Photorhabdus Virulence Cassettes: extracellular multi-protein needle complexes for delivery of small protein effectors into host cells.
I. Vlisidou, A. Hapeshi, J. R. J. Healey, K. Smart, G. Yang, N. R. Waterfield
This study identifies Pnf as a Rho-GTPase toxin delivered by Photorhabdus Virulence Cassettes (PVCs) to disrupt host cell cytoskeletons, showing PVCs function as long-range protein delivery systems.
bioRxiv · Feb 15, 2019 · PreprintMicrobiology