Leukemia inhibitory factor (LIF) receptor amplifies pathogenic activation of fibroblasts in lung fibrosis
Hung N. Nguyen, Yunju Jeong, Yunhye Kim, Mari Kamiya, Yaunghyun Kim, Humra Athar, Peter J. Castaldi, Craig P. Hersh, Jaivardhan A. Menon, Jessie Wong, Ian Chan, William M. Oldham, Robert F. Padera, Nirmal S. Sharma, Lynette Marie Sholl, , Michael B. Brenner
This study identifies LIFR as a master amplifier of fibroblast activation in IPF, showing that blocking LIFR reduces fibrosis in ex vivo tissue.
Proceedings of the National Academy of Sciences · Dec 5, 2024Peer-reviewedCell Biology