Author

Robert F. Padera

Brigham and Women's HospitalORCID 0000-0002-4571-5494Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:differential expression· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Approach:statistical model· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Assay:spatial transcriptomics· 2

Frequent Co-Authors

Adam L. Essene· 2 shared Alex K. ShalekiD· 2 shared Alexander SturmiD· 2 shared Alexandra–Chloé VillaniiD· 2 shared Ayshwarya SubramanianiD· 2 shared Carly G.K. ZiegleriD· 2 shared Caroline B. M. PorteriD· 2 shared Deborah Tan HungiD· 2 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Adam L. Essene

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4 papers

Recent·Most cited

A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients

Yered H. Pita-Juárez, Dimitra Karagkouni, Nikolaos Kalavros, Johannes C. Melms, Sebastian Niezen, Toni Marie Delorey, Adam L. Essene, Olga Rachel Brook, Deepti B. Pant, Disha Skelton-Badlani, Pourya Naderi Yeganeh, Pinzhu Huang, Liuliu Pan, TYLER D. HETHER, Tallulah S. Andrews, , Ioannis S. Vlachos

This study creates a single-nucleus and spatial transcriptomic atlas of the COVID-19 liver, revealing cellular and functional disruptions associated with organ damage.

Genome biology · Mar 14, 2025Peer-reviewedGenomics

Leukemia inhibitory factor (LIF) receptor amplifies pathogenic activation of fibroblasts in lung fibrosis

Hung N. Nguyen, Yunju Jeong, Yunhye Kim, Mari Kamiya, Yaunghyun Kim, Humra Athar, Peter J. Castaldi, Craig P. Hersh, Jaivardhan A. Menon, Jessie Wong, Ian Chan, William M. Oldham, Robert F. Padera, Nirmal S. Sharma, Lynette Marie Sholl, , Michael B. Brenner

This study identifies LIFR as a master amplifier of fibroblast activation in IPF, showing that blocking LIFR reduces fibrosis in ex vivo tissue.

Proceedings of the National Academy of Sciences · Dec 5, 2024Peer-reviewedCell Biology

Heteroplasmic Mitochondrial Genetic Variation in the Human Heart

Liying Xue, Xianbang Sun, Jesse D. Moreira, Yi Li, Karan K. Smith, Robert F. Padera, Marc E. Lenburg, Daniel A Levy, Emelia J. Benjamin, Deepa Mangalat Gopal, Chunyu Liu, Jessica L. Fetterman

The paper examines heteroplasmic mitochondrial genetic variants in human cardiac tissues and finds they differ from those in blood and skeletal muscle, with higher variant counts in cardiac tissue linked to age.

bioRxiv · Jul 13, 2022 · PreprintGenetics

A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2

Toni Marie Delorey, Carly G.K. Ziegler, Graham Heimberg, Rachelly Normand, Yiming Yang, Åsa Segerstolpe, Domenic Abbondanza, Stephen J. Fleming, Ayshwarya Subramanian, Daniel T. Montoro, Karthik A. Jagadeesh, Kushal K. Dey, Pritha Sen, Michal Slyper, Yered H. Pita-Juárez, , Alexandra–Chloé Villani

This study creates a single-cell and spatial atlas of autopsy tissues from COVID-19 patients, revealing altered cellular responses and potential therapeutic targets.

bioRxiv · Feb 25, 2021 · PreprintGenomics