Author

Gerald F. M. Watts

Brigham and Women's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 2 Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Assay:CITE-seq· 1

Frequent Co-Authors

Adam T. Chicoine· 3 shared Alessandra NervianiiD· 3 shared Ami Ben‐Artzi· 3 shared Amit LakhanpaliD· 3 shared Andrew C. CordleiD· 3 shared Andrew D. FileriD· 3 shared Andrew McDavidiD· 3 shared Anna Helena JonssoniD· 3 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Adam T. Chicoine

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Leukemia inhibitory factor (LIF) receptor amplifies pathogenic activation of fibroblasts in lung fibrosis

Hung N. Nguyen, Yunju Jeong, Yunhye Kim, Mari Kamiya, Yaunghyun Kim, Humra Athar, Peter J. Castaldi, Craig P. Hersh, Jaivardhan A. Menon, Jessie Wong, Ian Chan, William M. Oldham, Robert F. Padera, Nirmal S. Sharma, Lynette Marie Sholl, , Michael B. Brenner

This study identifies LIFR as a master amplifier of fibroblast activation in IPF, showing that blocking LIFR reduces fibrosis in ex vivo tissue.

Proceedings of the National Academy of Sciences · Dec 5, 2024Peer-reviewedCell Biology

Tissue-specific enhancer-gene maps from multimodal single-cell data identify causal disease alleles

Saori Sakaue, Kathryn Weinand, Shakson Isaac, Kushal K. Dey, Karthik A. Jagadeesh, Masahiro Kanai, Gerald F. M. Watts, Zhu Zhu, Accelerating Medicines Partnership® RA/SLE Program and Network, Jennifer Albrecht, Jennifer H. Anolik, William A. Apruzzese, Nirmal K. Banda, Jennifer L. Barnas, Joan M. Bathon, , Soumya Raychaudhuri

The paper develops SCENT, a method to create cell-type-specific enhancer-gene maps from single-cell multimodal data, identifying causal variants and genes for diseases.

Nature Genetics · Apr 1, 2024Peer-reviewedGenetic & Genomic Medicine

Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution

Joyce B. Kang, Amber Z. Shen, Saisriram Gurajala, Aparna Nathan, Laurie Rumker, Vitor R. C. Aguiar, Cristian Valencia, Kaitlyn A. Lagattuta, Fan Zhang, Anna Helena Jonsson, Seyhan Yazar, José Alquicira-Hernández, Hamed Khalili, Ashwin N. Ananthakrishnan, Karthik A. Jagadeesh, , Joseph E. Powell

The paper maps cell-type-specific eQTLs for HLA genes across multiple tissues and identifies dynamic regulation of HLA-DQ genes in immune cells.

Nature Genetics · Nov 30, 2023Peer-reviewedGenetic & Genomic Medicine

Cellular deconstruction of inflamed synovium defines diverse inflammatory phenotypes in rheumatoid arthritis

Fan Zhang, Anna Helena Jonsson, Aparna Nathan, Kevin Wei, Nghia Millard, Qian Xiao, María Gutiérrez‐Arcelus, William A. Apruzzese, Gerald F. M. Watts, Dana Weisenfeld, Joyce B. Kang, Laurie Rumker, Joseph Mears, Kamil Slowikowski, Kathryn Weinand, , Zhu Zhu

The paper deconstructs RA synovium using single-cell data to identify six cell type abundance phenotypes associated with distinct inflammatory states.

bioRxiv · Feb 25, 2022 · PreprintGenomics