Studies of infused megakaryocytes into mice support a ''catch-and release'' model of pulmonary-centric thrombopoiesis
Hyun‐Jun Kim, Danuta Jadwiga Jarocha, Ian Johnson, Hyun-Sook Ahn, Nicholas Hlinka, Deborah L. French, Lubica Rauova, Kiwon Lee, Mortimer Poncz
The paper shows that megakaryocytes are entrapped in the lungs, release cytoplasmic fragments, and undergo platelet formation, supporting a pulmonary-centric 'catch-and-release' model of thrombopoiesis.
bioRxiv · Jun 4, 2024 · PreprintCell Biology