Author

Danuta Jadwiga Jarocha

Children's Hospital of Philadelphia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Deborah L. FrenchiD· 2 shared Mortimer PoncziD· 2 shared Alexander G. McFarlandiD· 1 shared Aoife M. Roche· 1 shared Brian EsteveziD· 1 shared Davin Tafuri· 1 shared Elahe Kamali Ghahe· 1 shared Emma J. CookiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

Deborah L. FrenchORCID

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Author profile →

3 papers

Recent·Most cited

An integrated enzymatic and computational pipeline for quantifying off-target base-editing

Alexander G. McFarland, Soon‐Keat Ooi, Davin Tafuri, Elahe Kamali Ghahe, Natalie Cooper, Emma J. Cook, Shantan G. Reddy, Danuta Jadwiga Jarocha, Nils Wellhausen, Saar I. Gill, Aoife M. Roche, Joseph A. Fraietta, Frederic D. Bushman, Friederike Herbst

The paper introduces a combined enzymatic and computational pipeline to identify off-target base-editing sites in human cells on a genome-wide scale.

bioRxiv · Aug 26, 2025 · PreprintMolecular Biology

Studies of infused megakaryocytes into mice support a ''catch-and release'' model of pulmonary-centric thrombopoiesis

Hyun‐Jun Kim, Danuta Jadwiga Jarocha, Ian Johnson, Hyun-Sook Ahn, Nicholas Hlinka, Deborah L. French, Lubica Rauova, Kiwon Lee, Mortimer Poncz

The paper shows that megakaryocytes are entrapped in the lungs, release cytoplasmic fragments, and undergo platelet formation, supporting a pulmonary-centric 'catch-and-release' model of thrombopoiesis.

bioRxiv · Jun 4, 2024 · PreprintCell Biology

RUNX1 haploinsufficiency causes a marked deficiency of megakaryocyte-biased hematopoietic progenitor cells: Mechanistic studies and drug correction

Brian Estevez, Sara Borst, Danuta Jadwiga Jarocha, Varun S. Sudunagunta, Michael V. Gonzalez, James P. Garifallou, Hakon H. Hakonarson, Peng Gao, Kai Tan, Paul Liu, Sumedha Bagga, Nicholas Holdreith, Wei Tong, Nancy A. Speck, Deborah L. French, , Mortimer Poncz

This study shows that RUNX1 haploinsufficiency reduces megakaryocyte-biased hematopoietic progenitor cells and identifies drug targets to correct this defect.

bioRxiv · Aug 23, 2020 · PreprintMolecular Biology