Pre-TCR-Targeted Immunotherapy for T-cell Acute Lymphoblastic Leukemia
Patricia Fuentes, Marina García-Peydró, Juan Alcaín, Marta Mosquera, Carmela Cela, Claudia Cifuentes, Montserrat Torrebadell, Ignacio Isola, Mireia Camós, Manuel R. Ramírez, Balbino Alarcón, Marı́a L. Toribio
This study identifies the pre-TCR as a target for immunotherapy in T-ALL, showing that anti-pre-TCR antibodies inhibit leukemia-initiating cell activity and tumor progression in xenograft models.
Nature Immunology · Sep 1, 2025Peer-reviewedImmunology