Balbino Alarcón

The paper develops an ER retrieval-and-release system to study ligand-independent basal TCR signaling, finding that surface TCRs generate distinct phosphorylation patterns compared to ligand-induced activation.

This study identifies the pre-TCR as a target for immunotherapy in T-ALL, showing that anti-pre-TCR antibodies inhibit leukemia-initiating cell activity and tumor progression in xenograft models.

This study identifies TAF1-dependent transcriptional dysregulation as a mechanism underlying multiple sclerosis progression and presents an in vivo model for therapeutic development.

This study shows that SFRP1 from astrocytes promotes microglial activation in acute and chronic neuroinflammation, suggesting it as a therapeutic target.