UBE3A and transsynaptic complex NRXN1-CBLN1-GluD1 in a hypothalamic VMHvl-arcuate feedback circuit regulates aggression
Yi Nong, David C. Stoppel, Mark A. Johnson, Morgane Boillot, Jelena Todorovic, Jason Shen, Xinyu Zhou, Monica J. S. Nadler, Carrie L. Rodriguez, Yuda Huo, Ikue Nagakura, Ekkehard Matthias Kasper, Matthew P. Anderson
The paper identifies a hypothalamic feedback circuit involving UBE3A and the NRXN1-CBLN1-GluD1 complex that regulates aggression, showing how autism-related genetic defects impair this circuit.
bioRxiv · Feb 28, 2023 · PreprintNeuroscience