Structure informed xrRNA2 mutations in Zika virus provide a roadmap for vaccine development
Camille Merrick, Imali Kegode, Sarah Leach, Madeline Kale, Dustin L. Heiden, John David Beckham
This study introduces structure-informed mutations in ZIKV xrRNA2 to attenuate the virus and evaluate its potential as a vaccine, finding reduced virulence and complete protection in mice.
bioRxiv · May 29, 2026 · PreprintMicrobiology