Author

Sarah Leach

University of Colorado AnschutzORCID 0000-0002-1872-6446Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein design· 1 Assay:proteomics· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Angad P. MehtaiD· 1 shared Camille Merrick· 1 shared Diego J. Orea· 1 shared Dustin L. Heiden· 1 shared Graeme Lindsey· 1 shared Hui XuiD· 1 shared Imali Kegode· 1 shared Jenna J. GuthmilleriD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperSynthetic Biology

Angad P. MehtaORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Structure informed xrRNA2 mutations in Zika virus provide a roadmap for vaccine development

Camille Merrick, Imali Kegode, Sarah Leach, Madeline Kale, Dustin L. Heiden, John David Beckham

This study introduces structure-informed mutations in ZIKV xrRNA2 to attenuate the virus and evaluate its potential as a vaccine, finding reduced virulence and complete protection in mice.

bioRxiv · May 29, 2026 · PreprintMicrobiology

Virus-free continuous directed evolution in human cells using somatic hypermutation

Stanley Bram, Diego J. Orea, Graeme Lindsey, Soyu Zi, Jordan Quenneville, Hui Xu, Sarah Leach, Jenna J. Guthmiller, Angad P. Mehta

This paper develops a continuous directed evolution platform in human B cells using somatic hypermutation to evolve proteins with diverse mutations.

bioRxiv · Dec 24, 2024 · PreprintSynthetic Biology