Functional primary human 3D skeletal muscle models enable exercise and metabolic research
Simon I. Dreher, Robin Schoeler, Katharina S. Zorn, Jens Martin, Jana Kuehnle, Kevin Elsner, Imme Behle, Thomas Goj, Lara Ruoff, Kolja Leffek, Alessia Moruzzi, Peter Loskill, André Tomalka, Tobias Siebert, Andreas L. Birkenfeld, , Cora Weigert
The paper develops primary human skeletal muscle organoids that mimic metabolic and exercise responses, showing alignment with in vivo responses and detecting drug effects.
bioRxiv · Sep 9, 2026 · PreprintMolecular Biology