Simon I. Dreher

The paper develops primary human skeletal muscle organoids that mimic metabolic and exercise responses, showing alignment with in vivo responses and detecting drug effects.

This study identifies sex-specific molecular differences in human skeletal muscle and shows that endurance training reduces these differences.

This study investigates the role of ALK1/2/3 inhibition in mesenchymal stromal cell chondrogenesis, finding that BMP-ALK1/2/3 signaling is not a driver of hypertrophy and that PTHrP/hedgehog and WNT signaling are more critical in hypertrophic differentiation.