Mitochondrial sites of contact with the nucleus aid in chemotherapy evasion of glioblastoma cells
Daniela Strobbe, Mardja Bueno, Claudia De Vitis, Sarah Hassan, Danilo Faccenda, Krenare Bruqi, Elena Romano, Lucia Pedace, Andrey A. Yurchenko, Gurtej K. Dhoot, Ivi J Bistrot, Fábio Klamt, Luana Suéling Lenz, Eduardo Cremonese Filippi‐Chiela, Pietro Ivo D’Urso, , Michelangelo Campanella
This study identifies TSPO-mediated mitochondrial-nuclear contacts as a mechanism enabling glioblastoma cells to evade TMZ chemotherapy, showing that modulating TSPO restores chemosensitivity.
bioRxiv · Aug 27, 2024 · PreprintCancer Biology