Eduardo Cremonese Filippi‐Chiela

This study shows that metformin restores autophagy in TSC2 haploinsufficient and CRISPR-edited fibroblasts by blocking mTORC1, suggesting a potential therapeutic strategy for TSC.

The paper develops a functional autophagy gene set signature to classify autophagy states and links autophagy induction and lysosomal activity to poor prognosis in glioblastoma.

This study integrates single-cell, spatial transcriptomics, and bulk RNA data to identify TME subtypes and spatial niches in PDAC that correlate with patient survival.

This study identifies TSPO-mediated mitochondrial-nuclear contacts as a mechanism enabling glioblastoma cells to evade TMZ chemotherapy, showing that modulating TSPO restores chemosensitivity.