Michelangelo Campanella

Engineered flavonoid disrupts mitochondrial AIF/CHCHD4 complex for targeted cancer therapy

This paper identifies M30-E05, an engineered flavonoid that disrupts the AIF/CHCHD4 mitochondrial complex, reducing cancer cell viability and tumor growth in xenograft models.

Mitochondria drive microglial NRLP3 inflammasome activation via TSPO

This study shows TSPO on mitochondria promotes microglial inflammasome activation by stabilizing NLR proteins, inhibiting mitophagy, and enhancing pro-inflammatory gene expression, leading to excitotoxicity.

Whole-organism screening in a zebrafish model of CLN2 disease identifies pregnenolone as a modulator of lysosomal functions with anti-epileptic properties

This study identifies pregnenolone as a therapeutic candidate for CLN2 disease by suppressing seizures and normalizing lysosomal function in tpp1-/- zebrafish.

Canine Mammary Tumours (CMTs) exploit Mitochondrial Cholesterol for aggressive reprogramming

This study shows TSPO's role in aggressive canine mammary tumours by facilitating mitochondrial cholesterol handling, enhancing survival, and reducing Tamoxifen efficacy.

Mitochondrial sites of contact with the nucleus aid in chemotherapy evasion of glioblastoma cells

This study identifies TSPO-mediated mitochondrial-nuclear contacts as a mechanism enabling glioblastoma cells to evade TMZ chemotherapy, showing that modulating TSPO restores chemosensitivity.