Endothelial tight junctions and cell-matrix adhesions reciprocally control blood-brain barrier integrity
Gergő Porkoláb, Lucien Lemaitre, Beatrix Magyaródi, Imola Rajmon, Tibor Novák, Bálint Barna H. Kovács, Ilona Gróf, Anikó Szecskó, Kinga Dóra Kovács, Enikő Farkas, Boglárka Kovács, Inna Székács, Attila G. Végh, Yosuke Hashimoto, Chris Greene, , Mária A. Deli
This study shows that tight junctions and cell-matrix adhesions in brain endothelial cells reciprocally control blood-brain barrier integrity through mechanical forces and protein expression changes.
bioRxiv · Sep 6, 2025 · PreprintNeuroscience