Attila G. Végh

This study identifies a mechanism by which triple-negative breast cancer-derived extracellular vesicles disrupt the blood-brain barrier by downregulating PAQR5/mPRγ, leading to increased cancer cell migration into the brain.

This study shows that tight junctions and cell-matrix adhesions in brain endothelial cells reciprocally control blood-brain barrier integrity through mechanical forces and protein expression changes.