Misregulation of mitochondrial 6mA promotes the propagation of mutant mtDNA and causes aging in C. elegans
Anne Hahn, Grace Ching Ching Hung, Arnaud Ahier, Chuan-Yang Dai, Ina Kirmes, Brian M. Forde, Daniel Campbell, Rachel Shin Yie Lee, Josiah T. Sucic, Tessa Onraet, Steven Zuryn
This study shows that misregulation of mitochondrial 6mA in C. elegans reduces mtDNA copy number, impairs OXPHOS, increases oxidative stress, and shortens lifespan.
Cell Metabolism · Aug 22, 2024Peer-reviewedMolecular Biology