Germline mitophagy selectively eliminates deleterious mitochondrial DNA across generations
Arnaud Ahier, Tessa Onraet, Daniel Campbell, Brendan Townsend, Ayenachew Bezawork‐Geleta, Sasheen Dowlath, Anne Hahn, Rachel Shin Yie Lee, Chuan-Yang Dai, Arnaud Gaudin, Julia K. Pagan, Steven Zuryn
This study shows that germline mitophagy selectively removes mutant mitochondrial DNA in C. elegans, reducing their transmission to offspring across generations.
bioRxiv · Jul 27, 2026 · PreprintCell Biology