Chemical inhibition of the integrated stress response impairs the ubiquitin-proteasome system
Shanshan Xu, Maria E. Gierisch, Enrica Barchi, Ina Poser, Simon Alberti, Florian A. Salomons, Nico P. Dantuma
The paper shows that ISRIB impairs UPS degradation in the cytosol during proteotoxic stress, particularly affecting RQC and leading to UPS dysfunction.
bioRxiv · Mar 13, 2024Cell Biology