Author

Nico P. Dantuma

Karolinska InstitutetORCID 0000-0002-6090-4170Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell signaling & trafficking· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Enrica BarchiiD· 2 shared Florian A. SalomonsiD· 2 shared Maria E. GierischiD· 2 shared Ina Poser· 1 shared Luana NaiaiD· 1 shared Maria AnkarcronaiD· 1 shared Mirco MarognaiD· 1 shared Moritz H. WallnöferiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

Enrica BarchiORCID

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2 papers

Recent·Most cited

Mitochondria serve as a Holdout Compartment for Aggregation-Prone Proteins hindering Efficient Ubiquitin-Dependent Degradation

Maria E. Gierisch, Enrica Barchi, Mirco Marogna, Moritz H. Wallnöfer, Maria Ankarcrona, Luana Naia, Florian A. Salomons, Nico P. Dantuma

This study identifies mitochondrial localization as a barrier to ubiquitin-dependent degradation of aggregation-prone proteins, showing that inhibiting eIF5A reduces mitochondrial retention and enhances degradation.

bioRxiv · Feb 27, 2025 · PreprintCell Biology

Chemical inhibition of the integrated stress response impairs the ubiquitin-proteasome system

Shanshan Xu, Maria E. Gierisch, Enrica Barchi, Ina Poser, Simon Alberti, Florian A. Salomons, Nico P. Dantuma

The paper shows that ISRIB impairs UPS degradation in the cytosol during proteotoxic stress, particularly affecting RQC and leading to UPS dysfunction.

bioRxiv · Mar 13, 2024Cell Biology