Selective vulnerability of excitatory cortical neurons to ZMYND11 loss reveals cell-type-specific mechanisms of neurodevelopmental disorder risk
Xuyao Chang, Megan McKinley, Wenqi Li, Inah Yang, Elena Albizzati, Eri Iwasawa, Feng Guo, Amelle Shillington, Jason H. Tchieu
The paper shows that ZMYND11 loss selectively affects excitatory cortical neurons, causing hyperexcitability and molecular changes, while inhibitory neurons are less affected, revealing cell-type-specific mechanisms in neurodevelopmental disorders.
bioRxiv · Jun 19, 2026 · PreprintNeuroscience