Feng Guo

This paper develops a human myelin microphysiological system to test treatment responses in multiple sclerosis patients, showing differential demyelination and immune responses between patient groups.

This paper develops an acoustofluidic patch for transdermal biosensing and drug delivery, demonstrating its ability to detect and reverse acute allergic reactions in mice.

This paper introduces Brainobot, a biohybrid robotic system using brain organoid reservoir computing to enable real-world decision-making tasks like object grasping and laser chasing with high efficiency and low energy consumption.

This study quantifies information-processing-like properties of human cortical organoids using a functional phenotyping framework, linking network function to disease-related mutations and pharmacological perturbations.

This study investigates the effects of the SCN2A-L1342P mutation in human cortical organoids, finding increased neuronal excitability, enhanced synaptic transmission, and transcriptomic changes related to synaptic and developmental pathways.

The paper shows that ZMYND11 loss selectively affects excitatory cortical neurons, causing hyperexcitability and molecular changes, while inhibitory neurons are less affected, revealing cell-type-specific mechanisms in neurodevelopmental disorders.

This study shows PARP1 prevents TOP1 from causing deletions at STRs by inhibiting TOP1-DNA adduct formation, which could inform therapies for cancers with RNase H2 mutations.

This study investigates the role of ZMYND11 in neurodevelopment by analyzing its effects on cortical neural stem cells and splicing regulation in ASD risk factors.

This paper presents an OECT-based sensor for rapid, sensitive detection of extracellular vesicles in Alzheimer's disease, showing improved sensitivity and reduced detection time.

This paper introduces VID scaffolds to enhance diffusion in neural organoids, improving their function and drug response compared to conventional organoids.

This study uses human brain organoid microphysiological systems to show that AD patient monocytes cause increased inflammation and reduced Aβ clearance in organoids compared to controls.