Microbiota-sensitive glial and metabolic programs define a critical window in early postnatal brainstem development
Cristina Cuesta‐Marti, Caoimhe M. K. Lynch, Maya Davies, Indira Venkatesh, Austėja Balevičiūtė, Jessica Hincks, Lars Wilmes, Julia Eckenberger, Benjamín Valderrama, Jade A Lawless, Gerard M. Moloney, Subrata Ghosh, Gerard A. Clarke, John F. Cryan, Lily Keane
The paper investigates how early-life microbiota influences transcriptional and metabolic programs in the developing brainstem, identifying a critical window during which microbial colonization affects pathways linked to oligodendrocyte lineage progression and tumour biology.
bioRxiv · Jul 19, 2026 · PreprintNeuroscience