Tumor-Educated-Platelets interact with Breast Cancer-Stem-Cells via P-selectin- PSGL1 and ensure stemness and metastasis through WNT-β-Catenin-VEGF-VEGFR2 intra-cellular signaling: Therapeutic modulation by aspirin
Aishwarya Guha, Jasmine Sultana, Avishek Bhuniya, Mohona Chakravarti, Saurav Bera, Anirban Sarkar, Sukanya Dhar, Pritha Roy Choudhury, Prodipto Das, Juhina Das, Nilanjan Ganguly, Ipsita Guha, Dhrubajyoti Bairagya, Tapasi Das, Neyaz Alam, , Saptak Banerjee
This study identifies tumor-educated platelets (TEPs) interacting with breast cancer stem cells (BCSCs) via P-selectin-PSGL1 to promote stemness and metastasis through WNT-β-Catenin-VEGF-VEGFR2 signaling, and shows aspirin can reverse this effect.
Breast Cancer Research · Dec 15, 2025Peer-reviewedCancer Biology