CENP-B dynamics at centromeres is regulated by a SUMOylation/ubiquitination and proteasomal-dependent degradation mechanism involving the SUMO-targeted ubiquitin E3 ligase RNF4
Jhony El Maalouf, Pascale Texier, Indri Erliandri, Camille Cohen, Armelle Corpet, Frédéric Catez, Chris Boutell, Patrick Lomonte
This study identifies SUMOylation at K402 as a regulatory mechanism for CENP-B stability at centromeres through RNF4-mediated ubiquitination and proteasomal degradation.
bioRxiv · Jan 9, 2018 · PreprintCell Biology