Armelle Corpet

Defective plasticity in dermatomyositis patients muscle stem cells is associated with sustained intrinsic inflammatory signaling and disruption of the histone H3.3 chromatin loading pathway

This study identifies defective muscle stem cell plasticity in dermatomyositis patients, linked to chronic inflammation and disrupted H3.3 chromatin loading, impairing myogenesis.

A p97-PML NBs axis is essential for chromatin-bound cGAS untethering and degradation upon senescence-prone DNA damage

This study shows that p97 and PML nuclear bodies regulate cGAS degradation after DNA damage, affecting the DNA damage response and senescence.

The HUSH epigenetic repressor complex silences PML nuclear bodies-associated HSV-1 quiescent genomes

This paper identifies the HUSH-SETDB1-MORC2 complex as essential for maintaining HSV-1 latency by promoting H3K9me3 chromatin marks on viral genomes in neurons.

Interplay between PML NBs and HIRA for H3.3 dynamics following type I interferon stimulus

The paper identifies SUMO-SIM interactions as essential for HIRA recruitment to PML NBs and shows PML NBs regulate HIRA distribution and H3.3 deposition at ISGs during IFN-I response.

CENP-B dynamics at centromeres is regulated by a SUMOylation/ubiquitination and proteasomal-dependent degradation mechanism involving the SUMO-targeted ubiquitin E3 ligase RNF4

This study identifies SUMOylation at K402 as a regulatory mechanism for CENP-B stability at centromeres through RNF4-mediated ubiquitination and proteasomal degradation.