This study uses PacBio HiFi sequencing to assemble complete Plasmodium falciparum genomes from natural infections, revealing full repertoires of immune-related genes.

G3 Genes Genomes Genetics · Oct 27, 2026Peer-reviewedGenomics

The HUSH epigenetic repressor complex silences PML nuclear bodies-associated HSV-1 quiescent genomes

Simon Roubille, Tristan Escure, Franceline Juillard, Armelle Corpet, Rémi Néplaz, Olivier Binda, Coline Seurre, Mathilde Gonin, Stuart Bloor, Camille Cohen, Pascale Texier, Oscar L. Haigh, Olivier Pascual, Yonatan Ganor, Frédérique Magdinier, , Patrick Lomonte

This paper identifies the HUSH-SETDB1-MORC2 complex as essential for maintaining HSV-1 latency by promoting H3K9me3 chromatin marks on viral genomes in neurons.

Proceedings of the National Academy of Sciences · Nov 26, 2024Peer-reviewedMicrobiology

Interplay between PML NBs and HIRA for H3.3 dynamics following type I interferon stimulus

Constance Kleijwegt, Florent Bressac, Coline Seurre, Wilhelm Bouchereau, Camille Cohen, Pascale Texier, Thomas Simonet, Laurent Schaeffer, Patrick Lomonte, Armelle Corpet

The paper identifies SUMO-SIM interactions as essential for HIRA recruitment to PML NBs and shows PML NBs regulate HIRA distribution and H3.3 deposition at ISGs during IFN-I response.

eLife · May 5, 2023Peer-reviewedGenetics

CENP-B dynamics at centromeres is regulated by a SUMOylation/ubiquitination and proteasomal-dependent degradation mechanism involving the SUMO-targeted ubiquitin E3 ligase RNF4

Jhony El Maalouf, Pascale Texier, Indri Erliandri, Camille Cohen, Armelle Corpet, Frédéric Catez, Chris Boutell, Patrick Lomonte

This study identifies SUMOylation at K402 as a regulatory mechanism for CENP-B stability at centromeres through RNF4-mediated ubiquitination and proteasomal degradation.

bioRxiv · Jan 9, 2018 · PreprintCell Biology