Axon Regeneration and Functional Recovery after Spinal Cord Injury is Enhanced by Allele-Specific ApoE Neuronal Action through LRP8
Ramakrishnan Kannan, Xingxing Wang, LaShae Nicholson, Nancy Z. Lin, Elisa M. Howard, Atrayee Basu, Ines Ingabire, Yuichi Sekine, Stephen M. Strittmatter
This study shows that ApoE2 overexpression via AAV improves axon regeneration and motor function after spinal cord injury through LRP8 signaling without affecting inflammation or scarring.
bioRxiv · Oct 10, 2025 · PreprintNeuroscience