LaShae Nicholson

This study shows that a high-fat, high-sugar diet worsens cognitive deficits in Alzheimer's mouse models through metabolic stress in specific brain cells, independent of amyloid or tau pathology.

This study shows that ApoE2 overexpression via AAV improves axon regeneration and motor function after spinal cord injury through LRP8 signaling without affecting inflammation or scarring.

This study shows that PrPC is necessary for synapse loss, phospho-tau accumulation, and neuronal gene expression changes in Alzheimer's knock-in mice, suggesting targeting the Aβo-PrPC interaction could prevent these pathologies.