The APL1 immune factor is encoded by a single ancestral gene in most Anopheles species and expanded to three paralogs with distinct function in the Anopheles gambiae complex
Christian Mitri, Emmanuel Bischoff, Karin Eiglmeier, Inge Holm, Constentin Dieme, Emma Brito‐Fravallo, Abbasali Raz, Sedigheh Zakeri, Mahdokht Ilbeigi Khamseh Nejad, Navid Dinparast Djadid, Kenneth D. Vernick, Michelle M. Riehle
This study identifies APL1 as a single ancestral gene in most Anopheles species and shows its expansion to three paralogs in the Gambiae complex, with distinct functional roles in immunity and malaria transmission.
Parasites & Vectors · Jan 13, 2020Peer-reviewedGenetics