Insulin preservatives trigger neutrophil extracellular trap formation through SYNE1-mediated nuclear disassembly
Ulrike Klueh, Ingrida Oendraite, Priscila Silva Cunegundes, Kenneth Wood, Karolis Krinickis, Paul M. Stemmer, Kaitlin Lowran, Don L. Kreutzer, Ronald J. Pettis
This study shows that insulin preservatives induce NETosis through SYNE1 disruption, reducing inflammation in a porcine model when preservatives are removed.
bioRxiv · Jun 9, 2026 · PreprintImmunology