Metabolic Rewiring by alpha-Synuclein Enables Mitohormetic Protection
Shay Geula, Inna Grosheva, Yehudit Zaltsman, Limor Regev, Sabita Chourasia, Atan Gross
This study shows that alpha-synuclein expression in HEK293 cells rewires metabolism to enhance mitochondrial resilience and provides protection against respiratory complex I inhibition.
bioRxiv · Dec 7, 2025 · PreprintCell Biology