In vitro Characterization of Peptidomimetic Proteolysis Targeting Chimera (PROTAC) as a Degrader of 3-Chymotrypsin-Like Protease (Mpro/3CLpro) against SARS-CoV-2
Mirko Giuseppe Liturri, Annalisa Bergna, Alessia Lai, Carla Della Ventura, Arianna Gabrieli, Ioana Seravalli, Simone Ciofi‐Baffoni, Elena Lenci, Andrea Trabocchi, Stefano Rusconi
The paper characterizes FT235, a PROTAC degrader of SARS-CoV-2 3CLpro, showing antiviral activity and reduced cytotoxicity.
bioRxiv · Oct 30, 2025 · PreprintMicrobiology