Lactobacillus crispatus S-layer proteins modulate innate immune response and inflammation in the lower female reproductive tract.
Alexiane C. Decout, Ioannis Krasias, Lauren A. Roberts, Belen Gimeno-Molina, Chloé Charenton, Daniel Brown Romero, Qiong Yu Tee, Julian Roberto Marchesi, Sherrianne Ng, Lynne Sykes, Phillip R. Bennett, David A. MacIntyre
This study shows how Lactobacillus crispatus surface proteins modulate immune responses by shielding TLR ligands and interacting with anti-inflammatory receptors, reducing inflammation in the vaginal tract.
Nature Communications · Dec 30, 2024Peer-reviewedMicrobiology