David A. MacIntyre

Late-Onset Preeclampsia is characterised by Accelerated Placental Aging

This study identifies oxidative stress and TERRA loss as drivers of placental aging in late-onset preeclampsia, showing antioxidant treatment can mitigate these effects.

Multi-omic analysis of vaginal bacteria:host immune and metabolic interactions in adverse early pregnancy outcomes

This study investigates host-microbe interactions in early pregnancy by analyzing vaginal bacteria, immune responses, and metabolic profiles to identify markers of adverse outcomes.

KODAMA enables self-guided weakly supervised learning in spatial transcriptomics

KODAMA improves spatial transcriptomics analysis by reducing dimensionality while preserving spatial information, showing high accuracy across multiple datasets.

Dynamic roles of ILC3 in endometrial repair and regeneration

This study identifies two subsets of ILC3 in the human endometrium, showing their distinct roles in repair and regeneration during different physiological states.

Lactobacillus crispatus S-layer proteins modulate innate immune response and inflammation in the lower female reproductive tract.

This study shows how Lactobacillus crispatus surface proteins modulate immune responses by shielding TLR ligands and interacting with anti-inflammatory receptors, reducing inflammation in the vaginal tract.

Characterisation and comparison of semen microbiota and sperm function in men with infertility, recurrent miscarriage, or proven fertility

This study compares semen microbiota and sperm function in men with infertility, recurrent miscarriage, or proven fertility, finding no overall association but highlighting Flavobacterium's potential role.

Large-scale characterisation of the pregnancy vaginal microbiome and sialidase activity in a low-risk Chinese population

The paper characterizes the vaginal microbiome and sialidase activity in 2689 Chinese pregnant women, finding no association with preterm birth risk.

Proteome-wide prediction of bacterial carbohydrate-binding proteins as a tool for understanding commensal and pathogen colonisation of the vaginal microbiome

The paper predicts bacterial carbohydrate-binding proteins (lectins) across genomes to explore their role in vaginal microbiome colonization and pathogenicity.