TCRζ-Driven Pre-Signaling Organization of Lck in Rab11⁺ Endosomes Shapes TCR Activation
KONSTANTINA KARPOUZOU, Nikolaos Koutras, Ioannis Tyritidis, Evangelos Tsioupros, Andriana G. Kotini, VASILEIOS ROUKOS, Konstantina Nika
The paper identifies a standalone TCRζ pool in endosomes that recruits Lck and CD45 to form pre-activated signaling platforms, enhancing TCR activation efficiency.
Cellular & Molecular Biology Letters · Jul 8, 2026Peer-reviewedImmunology