ImmunologyCellular & Molecular Biology LettersPeer-reviewed
TCRζ-Driven Pre-Signaling Organization of Lck in Rab11⁺ Endosomes Shapes TCR Activation
KONSTANTINA KARPOUZOU, Nikolaos Koutras, Ioannis Tyritidis…·Konstantina Nika
The paper identifies a standalone TCRζ pool in endosomes that recruits Lck and CD45 to form pre-activated signaling platforms, enhancing TCR activation efficiency.
DOI 10.1186/s11658-026-00993-x