Structural Basis of Human Kinetochore-Microtubule Coupling by the Ndc80 and Ska Complexes
Ju Zhou, Ipsita Saha, Valerie Siahaan, Yuanchang Zhao, Carsten Janke, Ahmet Yıldız, Eva Nogales
Cryo-EM shows human Ndc80 and Ska complexes bound to adjacent microtubule protofilaments, linked by a SKA3 tether that passes Ska's preference for GTP-like lattice and tip tracking to Ndc80.
bioRxiv · Oct 10, 2026 · PreprintBiophysics✦ In-depth digest