Ahmet Yıldız

The Molecular Interplay of Tau and Motor Proteins on Microtubules

This study investigates how tau protein regulates motor proteins on microtubules using single-molecule imaging, cryo-EM, and MD simulations, revealing distinct mechanisms for inhibiting kinesin-1 and dynein.

Structural Basis of Human Kinetochore-Microtubule Coupling by the Ndc80 and Ska Complexes

Cryo-EM shows human Ndc80 and Ska complexes bound to adjacent microtubule protofilaments, linked by a SKA3 tether that passes Ska's preference for GTP-like lattice and tip tracking to Ndc80.

Stepping dynamics of dynein characterized by MINFLUX

This study uses MINFLUX to track yeast dynein stepping dynamics at high resolution, revealing ATP hydrolysis per step and 8 nm steps with transient plus-end movements.

Microtubule Lattice Spacing Governs MAP-Motor Regulation

The paper investigates how microtubule lattice spacing affects MAP binding and kinesin-1 motility, revealing that lattice spacing, not tubulin PTMs, primarily regulates these processes.

CDK1-dependent N-terminal NuMA phosphorylation promotes dynein-dynactin-NuMA assembly for accurate chromosome segregation

This study shows CDK1-dependent phosphorylation of NuMA's N-terminus is essential for dynein-dynactin-NuMA complex formation, ensuring accurate chromosome segregation.

Activation and regulation of the dynein-dynactin-NuMA complex

This study investigates how NuMA activates dynein and regulates microtubule dynamics during mitosis using structural and functional analyses.

A mechanism-aware stoichiometry platform resolves functional viral thresholds and induces antiviral hypersensitivity

The paper introduces a mechanism-aware platform to determine functional viral enzyme thresholds, revealing differences in stoichiometric requirements and enabling antiviral hypersensitivity detection.

Structure and mechanism of microtubule stabilization and motor regulation by MAP9

This study identifies MAP9 as a microtubule stabilizer that promotes neuronal morphogenesis and differentially regulates kinesin motor activity.

Enhanced Processivity and Collective Force Production of Kinesin-1 at Low Radial Forces

This study shows that kinesin-1 can generate collective forces efficiently under low radial forces, challenging previous views on its detachment behavior.

NuMA mechanically reinforces the spindle independently of its partner dynein

This study shows NuMA reinforces the spindle mechanically through microtubule crosslinking, independent of dynein, by bundling microtubules and stabilizing spindle poles under force.

Nde1 Promotes Lis1 Binding to Full-Length Autoinhibited Human Dynein-1

The paper shows Nde1 enhances Lis1 binding to autoinhibited dynein, facilitating Phi conformation opening through a novel intermediate state.

From Attraction to Repulsion: Omicron-Driven Rewiring of Nanobody Interfaces on the SARS-CoV-2 RBD

This study uses molecular dynamics simulations to analyze how Omicron mutations affect nanobody binding to the SARS-CoV-2 RBD, revealing structural changes and reduced binding stability.

Protection of the Telomeric Junction by the Shelterin Complex

This study investigates how the shelterin complex protects the telomeric junction by bridging single- and double-stranded telomeric DNA, enhancing POT1 binding stability and junction protection.

Cryo-EM shows how dynactin recruits two dyneins for faster movement

The paper shows that adaptors like BICDR1 and HOOK3 recruit two dyneins to dynactin, increasing force and speed compared to BICD2's single dynein recruitment.