Carsten Janke

Evolution Shapes Cortical Interneuron Migration

This study compares cortical interneuron migration across species, finding that human interneurons migrate slower and more dispersedly due to CCP1-dependent changes in microtubule dynamics.

Surface-induced tau condensation generates a selective microenvironment around microtubules

This study shows tau forms multilayered condensates on microtubules via a prewetting-like transition, creating a selective microenvironment that restricts some proteins while recruiting others.

Structural Basis of Human Kinetochore-Microtubule Coupling by the Ndc80 and Ska Complexes

Cryo-EM shows human Ndc80 and Ska complexes bound to adjacent microtubule protofilaments, linked by a SKA3 tether that passes Ska's preference for GTP-like lattice and tip tracking to Ndc80.

Reduced Microtubule Polyglutamylation Perturbs Neuronal Function and Accelerates Tau-Induced Neurodegeneration

This study shows that reduced microtubule polyglutamylation causes neuronal dysfunction and worsens Tau-induced neurodegeneration in mice.

Loss of Tubulin Tyrosination in Purkinje Neurons Does Not Cause Their Degeneration

This study shows that loss of tubulin tyrosination in Purkinje neurons does not lead to their degeneration, unlike polyglutamylation dysregulation.

Coupling of tubulin acetylation to microtubule stabilization through molecular mimicry

This study identifies MTCL1 as a factor linking microtubule stabilization and acetylation, showing its role in neuronal function through molecular mimicry.

Cytosolic factors govern vimentin network architecture and mechanics

This study reconstitutes vimentin networks in vitro using cell extracts, showing that cytosolic factors, not filament properties, determine network architecture and mechanics, which vary by cell type.

Organelle distribution and protein translation defects in radial glia cells with mutations in Eml1

The paper investigates Eml1 mutations in mice, finding altered organelle distribution and translation defects in radial glia cells, contributing to subcortical heterotopia.

TTLL6-mediated Polyglutamylation of PurA Maintains Colonic Crypt Integrity

This study identifies TTLL6 as a key polyglutamylase in the colon, showing its role in maintaining crypt integrity and preventing colon cancer progression.

Microtubule remodeling by the innate immune factor Trim69 compromises dynein-dependent migration of HIV virion cores towards the nucleus

The paper shows Trim69 remodels microtubules to inhibit HIV virion core migration by stalling dynein/dynactin complexes.

Ccp1 depletion disrupts network integration of hippocampal parvalbumin interneurons

This study shows that Ccp1 depletion in hippocampal parvalbumin interneurons leads to hyperglutamylation, impaired axonal transport, and reduced perisomatic inhibition of pyramidal cells in the CA2 region.

Mass spectrometry reveals novel features of tubulin polyglutamylation in the flagellum of Trypanosoma brucei

The paper develops a mass spectrometry pipeline to quantify tubulin polyglutamylation in Trypanosoma brucei flagella, identifying novel glutamylation sites and crosstalk with detyrosination.

Tubulin isotypes polymerise into sectioned microtubules that locally regulate protein binding

The paper shows that co-polymerization of different tubulin isotypes creates sectioned microtubules that differentially bind MAPs like TPPP1 and OPTN.

Cell-free Reconstitution Reveals Synergistic Stabilization of Microtubule Doublets by PACRG and FAP20

The paper uses cell-free assays to show PACRG and FAP20 synergistically stabilize microtubule doublets by reducing B-tubule depolymerization and increasing rescue frequency.

Prolyl isomerase FKBP12 reduces axon growth and negatively regulates microtubule polymerization by inhibiting CRMP2A

This paper shows FKBP12 inhibits CRMP2A-mediated microtubule polymerization and axon growth by binding to unphosphorylated CRMP2A.

Intrinsic microtubule destabilization of multiciliated choroid plexus epithelial cells during postnatal lifetime

The paper shows that choroid plexus cilia undergo axoneme resorption through microtubule destabilization, controlled by polyglutamylation and spastin, and is conserved in human samples.

Tubulin polyglutamylation patterns are central to axon guidance via selective regulation of microtubule-severing enzymes

The paper shows that tubulin polyglutamylation regulates microtubule-severing enzymes in axon guidance, with TTLL6 and TTLL11 having distinct roles in zebrafish and mammalian neurons.

ATAT1-enriched vesicles promote microtubule acetylation via axonal transport

This study shows that ATAT1-enriched vesicles are transported along axons to acetylate -tubulin, essential for proper vesicular transport.