Endothelial GATA6 deficiency suppresses intracellular TLR3-interferon signaling in HPAECs and promotes interferon response in HPASMCs
Vrinda Dambal, Iram Zaia, Dmitry A. Goncharov, Tapan Dey, Iryna Zhyvylo, Elena A. Goncharova, Maria E. Trojanowska
This study shows that GATA6 deficiency in endothelial cells reduces TLR3-interferon signaling and promotes interferon responses in adjacent smooth muscle cells through paracrine effects.
bioRxiv · Dec 11, 2025 · PreprintMolecular Biology