Maria E. Trojanowska

This study identifies ERG-EDNRB signaling in lymphatic endothelial cells as critical for junctional plasticity and fluid clearance in pulmonary fibrosis, showing that its disruption protects against fibrosis.

The paper identifies ACKR1-expressing venous endothelial cells as key drivers of fibrosis in IPF and shows ACKR1 inhibition reduces fibrosis in vivo.

This study shows that GATA6 deficiency in endothelial cells reduces TLR3-interferon signaling and promotes interferon responses in adjacent smooth muscle cells through paracrine effects.