Crosstalk of platelets with macrophages and fibroblasts aggravates inflammation, aortic wall stiffening, and osteopontin release in abdominal aortic aneurysm
Markus Udo Wagenhäuser, Joscha U Mulorz, Kim Jürgen Krott, Agnes Bosbach, Tobias Feige, Yae Hyun Rhee, Madhumita Chatterjee, Niklas Petzold, Christopher Böddeker, Wiebke Ibing, Irena Krüger, Ana M Popovic, Ann N. Roseman, Joshua Michael Spin, Philip S. Tsao, , Margitta Elvers
This study shows platelets worsen AAA by promoting inflammation, ECM degradation, and osteopontin release, with platelet depletion reducing aneurysm growth.
Cardiovascular Research · Nov 17, 2023Peer-reviewedMolecular Biology