Margitta Elvers

Dysregulated Platelet GPIb alpha - VWF Signalling in Abdominal Aortic Aneurysm formation and Progression

This study identifies dysregulated GPIb alpha-VWF signalling in AAA, showing increased platelet GPIb alpha expression and VWF activity in patients and mice.

The heart-liver axis controls platelet turnover by hepatic STAT3 phosphorylation and TPO regulation after acute myocardial infarction

Elevated IL-1 beta plasma levels, altered platelet activation and cardiac remodeling lead to moderately decreased LV function in Alzheimer transgenic mice after myocardial ischemia and reperfusion

This study shows that Alzheimer's transgenic mice experience reduced left ventricular function after myocardial ischemia and reperfusion, linked to elevated IL-1 beta, altered platelet activation, and cardiac remodeling.

Crosstalk between thrombospondin-1 and CD36 modulates platelet-RBC interaction limiting thrombosis and abdominal aneurysm formation

This study identifies a novel CD36-TSP-1 signaling pathway that modulates platelet-RBC interaction, promoting thrombus formation and contributing to abdominal aortic aneurysm pathology.

Platelets from early-stage Alzheimer patients show enhanced amyloid binding, an elevated open canalicular system and sex-specific differences in their activation profile

The paper shows that platelets from early-stage Alzheimer's patients bind more amyloid-beta, have altered morphology, and show sex-specific activation differences, suggesting potential as biomarkers for AD.

Long-term antiplatelet therapy protects against cerebral but not parenchymal amyloid plaque formation and neurodegeneration in transgenic mice of Alzheimers disease

This study shows that long-term antiplatelet therapy with clopidogrel reduces cerebral amyloid angiopathy and soluble Aβ42 levels but not parenchymal amyloid plaques or neurodegeneration in APP23 mice.

Platelets induce cell apoptosis of cardiac cells via FasL after acute myocardial infarction

This study shows that platelets induce cardiac cell apoptosis via FasL after acute myocardial infarction, contributing to cardiac damage and dysfunction.

Crosstalk of platelets with macrophages and fibroblasts aggravates inflammation, aortic wall stiffening, and osteopontin release in abdominal aortic aneurysm

This study shows platelets worsen AAA by promoting inflammation, ECM degradation, and osteopontin release, with platelet depletion reducing aneurysm growth.

Cryo-EM Structures of Amyloid-β Fibrils from Alzheimer's Disease Mouse Models

The paper presents cryo-EM structures of Aβ fibrils from Alzheimer's disease mouse models and compares them to human fibrils.