Age-related loss of brain demyelinating and remyelinating potential is overcome by microglia renewal
Athena Boutou, Ilias Roufagalas, Irini Papazian, Gianmarco Abbadessa, Konstantina Asprou, Owain W. Howell, Maria Kourouvani, Makoto Sainouchi, Ildikó Farkas, Vasiliki Pogka, Dimitrios Christos Tremoulis, Timokratis Karamitros, Hans Lassmann, Richard S. Nicholas, Jan Bauer, Lesley Probert
This study shows that aging impairs microglial function in demyelination and remyelination, but microglia replacement can restore these processes in aged mice.
bioRxiv · Jun 18, 2026 · PreprintImmunology